The Genome Institute of Singapore (GIS) is the national flagship for genomic sciences, driving cutting‑edge research at the intersection of biology, engineering, and medicine. This position is offered in the Laboratory of AI in Genomics led by Prof. Mile Sikic, which uses advanced bioinformatics and deep learning approaches to develop next‑generation models for genomic data analysis. GIS offers a dynamic and collaborative environment with close ties to world‑class universities and industry.

De novo genome assembly has been one of the most challenging problems in genomics. With new long‑read sequencing technologies, new assemblers, and high‑quality benchmarks, most of the human chromosomes can now be assembled. This project will focus on assembling human cancer genomes, which are especially difficult due to heterogeneity. We aim to reconstruct cancer genomes by comparing them to normal tissue genomes.