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Principal Scientist I – LC-MS/MS

Synexa Life Sciences | Macclesfield, United Kingdom | Posted June 20, 2026

Position Overview

Role Overview
We are seeking a Principal Scientist – LC-MS/MS Bioanalysis (PK/PD, Complex Modalities) to act as a subject matter expert across LC-MS/MS bioanalytical programmes supporting PK and PD studies. This role provides scientific leadership across multiple studies, focusing on complex problem-solving, assay strategy, and client engagement.

Key Responsibilities
  • Provide scientific leadership and SME support across LC-MS/MS studies
  • Lead troubleshooting of complex analytical challenges, including matrix effects, sensitivity limitations, and assay robustness
  • Advise on method development, optimisation, and validation strategies
  • Support study teams in resolving technical issues and ensuring consistent assay performance
  • Contribute to client interactions, including scientific discussions, data interpretation, and method justification
  • Support proposals, bid defences, and scientific strategy discussions
  • Mentor a...

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