The efficacy of drugs is governed by the solid-state form of their active pharmaceutical ingredients (APIs). APIs are typically dispersed in their crystalline form mixed with excipients such as cellulose or lactose. The arrangement of API molecules within the crystal lattice determines solubility, stability, and oral bioavailability of drugs, as well as their patentability. Controlling the solid state is therefore crucial for the therapeutic performance and commercial success of new drug candidates. This importance is reflected in two key challenges for the pharmaceutical industry: (i) poor solubilit...