Summary

Dr. Shin is seeking a PhD post-doctoral fellow for the project, which is VA merit grant funded, entitled “Role of ATRX, a chromatin remodeler, in immunotherapy response.”  This project aims to study the role of ATRX which is SWI/SNF-like ATP dependent chromatin remodeler, has various role in human cancer development and well-studied in the field of glioma. The current project is interrogating the role of ATRX in immunotherapy response using murine and cell line models that includes genetically engineered lung cancer model. Cell line model demonstrated accelerated tumor growth upon immunotherapy when cancer cell lost ATRX expression. Therefore, the study has potential to contribute to new biological insight on epigenetic mechanisms of resistance and develop new therapeutic strategy. Postdoctoral Associate wi...